教育经历

2003-2008 美国密歇根大学，生物化学，博士
1998-2002 北京大学，生物化学及分子生物学，学士

 

 

工作经历

2014-至今   北京大学生命科学学院，助理教授、长聘副教授

2014-至今   北大清华联合中心，研究员/独立PI

2009-2013  美国加州大学圣地亚哥分校，博士后，项目科学家

研究简介

1.  肖俊宇团队通过生物化学和结构生物学手段研究与人体疾病密切相关的蛋白分子，尤其聚焦对免疫球蛋白的研究。阐明人源IgM组装和黏膜转运机制，改变了对IgM五聚体的传统理解。系统分析了FcμR受体对不同形式IgM的识别，为深入理解IgM相关的免疫通路奠定基础。研究了分泌型IgA的组装机制，并揭示其被肺炎链球菌黏附蛋白识别的基础。

2.  2021年6月加入昌平实验室以来，肖俊宇带领团队积极参与抗击新冠病毒攻关研究，系统分析了一系列新冠病毒中和抗体的分子机制，为开发新冠病毒中和抗体药物奠定了基础。

 

主要荣誉

2022   北京市科学技术奖科学技术进步奖二等奖（第四完成人）

2021   药明康德生命化学研究奖-杰出成就奖

2021   顾孝诚讲座奖

2020   中源协和生命医学奖-创新突破奖

2019   国家自然科学基金委优秀青年基金

 

代表性成果

1. Li, Y., Wang, G., Li, N., Wang, Y., Zhu, Q., Chu, H., Wu, W., Tan, Y., Yu, F., Su, X.D., Gao, N., Xiao, J.* (2020). Structural insights into immunoglobulin M. Science 367:1014-1017.

2. Li, Y., Shen, H., Zhang, R., Ji, C., Wang, Y., Su, C., Xiao, J.* (2023). Immunoglobulin M Perception by FcμR. Nature Online ahead of print.

3. Wang, Y., Wang, G., Li, Y., Zhu, Q., Shen, H., Gao, N., Xiao, J.* (2020). Structural insights into secretory immunoglobulin A and its interaction with a pneumococcal adhesin. Cell Research 30:602-609.

4. Du, S., Cao, Y., Zhu, Q., Yu, P., Qi. F., Wang, G., Du, X., Bao, L., Deng, W., Zhu, H., Liu, J., Nie, J., Zheng, Y., Liang, H., Liu, R., Gong, S., Xu, H., Yisimayi, A., Lv, Q., Wang, B., He, R., Han, Y., Zhao, W., Bai, Y., Qu, Y., Gao, X., Ji, C., Wang, Q., Gao, N., Huang, W., Wang, Y., Xie, S.X.*, Su, X.D.*, Xiao, J.*, Qin, C.* (2020). Structurally resolved SARS-CoV-2 antibody shows high efficacy in severely infected hamsters and provides a potent cocktail pairing strategy. Cell 183:1013-1023.

5. Cao, Y.*, Yisimayi, A., Jian, F., Song, W., Xiao, T., Wang, L., Du, S., Wang, J., Li, Q., Chen, X., Yu, Y., Wang, P., Zhang, Z., Liu, P., An, R., Hao, X., Wang, Y., Wang, J., Feng, R., Sun, H., Zhao, L., Zhang, W., Zhao, D., Zheng, J., Yu, L., Li, C., Zhang, N., Wang, R., Niu, X., Yang, S., Song, X., Chai, Y., Hu, Y., Shi, Y., Zheng, L., Li, Z., Gu, Q., Shao, F., Huang, W., Jin, R., Shen, Z.*, Wang, Y.*, Wang, X.*, Xiao, J.*, Xie, X.S.* (2022). BA.2.12.1, BA.4 and BA.5 escape antibodies elicited by Omicron infection. Nature 608:593-602.

6. Cao, Y.*, Wang, J., Jian, F., Xiao, T., Song, W., Yisimayi, A., Huang, W., Li, Q., Wang, P., An, R., Wang, J., Wang, Y., Niu, X., Yang, S., Liang, H., Sun, H., Li, T., Yu, Y., Cui, Q., Liu, S., Yang, X., Du, S., Zhang, Z., Hao, X., Shao, F., Jin, R., Wang, X.*, Xiao, J.*, Wang, Y.*, Xie, X.S.* (2022). Omicron escapes the majority of existing SARS-CoV-2 neutralizing antibodies. Nature 602:657-663.

7. Liang, K., Li, N., Wang, X., Dai, J., Liu, P., Wang, C., Chen, X.W., Gao, N., Xiao, J.* (2018). Cryo-EM structure of human mitochondrial trifunctional protein. Proc Natl Acad Sci U S A 115:7039-7044.

8. Zhang, H., Zhu, Q., Cui, J., Wang, Y., Chen, M.J., Guo, X., Tagliabracci, V.S., Dixon, J.E., Xiao, J.* (2018). Structure and evolution of the Fam20 kinases. Nature Communications 9:1218.

9. Cui, J., Zhu, Q., Zhang, H., Cianfrocco, M.A., Leschziner, A.E., Dixon, J.E.*, Xiao, J.* (2017). Structure of Fam20A reveals a pseudokinase featuring a unique disulfide pattern and inverted ATP-binding. eLife 6, e23990.

10. Zhu, Q., Venzke, D., Walimbe, A.S., Anderson, M.E., Fu, Q., Kinch, L.N., Wang, W., Chen, X., Grishin, N.V., Huang, N., Yu, L., Dixon, J.E., Campbell, K.P.*, Xiao, J.* (2016). Structure of protein O-mannose kinase reveals a unique active site architecture. eLife 5, e22238.