教育经历

2014-2019，莱斯大学，计算生物物理，博士

2010-2014，北京大学，生物学，学士

工作经历

2024-至今， 昌平实验室，科学家

2018-2024，北京星亢原生物科技有限公司，创始人团队，副总裁

研究简介

专注于人工智能/计算驱动的生物分子动态、蛋白质折叠、蛋白质相互作用以及药物设计。重点研究人工智能驱动的抗体分子等生物大分子的设计和成药性优化。

 

近年主要研究成果包括：

1）在蛋白动力学和蛋白相互作用上，在PNAS，Nat Comm，JACS等期刊上以第一作者/共同第一作者发表论文十多篇；

2）参与设计的CD24抗体是中国首个人工智能设计优化的单抗拿到了美国FDA的IND批准；设计多个大小分子药物进入到PCC阶段；多个计算设计的候选药物达成总额上亿人民币的授权转让；

3）2018年带队参加结构预测大赛CASP13，获得free modeling领域第六名；

4)  发表专利申请/专利优先权申请多项。

主要荣誉

 2020年，HiCool全球创业大赛一等奖

 2020年，入选北京市高层次人才计划

代表性成果

1. Chen, M*., Jin, S*., Chen, X*., Bueno, C. and Wolynes, P.G., 2023. The marionette mechanism of domain–domain communication in the antagonist, agonist, and coactivator responses of the estrogen receptor. Proceedings of the National Academy of Sciences, 120(6), p.e2216906120.

2. Chen, M., Chen, X., Schafer, N.P., Clementi, C., Komives, E.A., Ferreiro, D.U. and Wolynes, P.G., 2020. Surveying biomolecular frustration at atomic resolution. Nature Communications, 11(1), pp.1-9.

3. Chen, M*., Jin, S*., Chen, X*., Bueno, C., Lu, W., Schafer, N.P., Lin, X., Onuchic, J.N. and Wolynes, P.G., 2020. Protein structure prediction in CASP13 using AWSEM-suite. Journal of chemical theory and computation, 16(6), pp.3977-3988. (Cover Story).

4. Chen, M*., Chen, X*., Schafer, N.P. and Wolynes, P.G., 2020. Exploring the interplay between fibrillization and amorphous aggregation channels on the energy landscapes of tau repeat isoforms. Proceedings of the National Academy of Sciences, 117(8), pp.4125-4130.

5. Chen, M*., Lin, X*., Lu, W., Schafer, N., Onuchic, J. N., & Wolynes, P. G. Template-Guided Structure Prediction and Refinement with an Optimized Folding Landscape Forcefield. Journal of chemical theory and computation 14, no. 11 (2018): 6102-6116.

6. Chen, M., Schafer, N., Zheng, W., & Wolynes, P. G. (2017). The AWSEM-Amylometer: Predicting Amyloid Propensity And Fibril Topology Using An Optimized Folding Landscape Model. ACS Chemical Neuroscience, 138842.

7. Chen, M., & Wolynes, P. G. (2017). Aggregation landscapes of Huntingtin exon 1 protein fragments and the critical repeat length for the onset of Huntington’s disease. Proceedings of the National Academy of Sciences, 114(17), 4406-4411.

8. Chen, M., Tsai, M., Zheng, W., & Wolynes, P. G. (2016). The Aggregation Free Energy Landscapes of Polyglutamine Repeats. Journal of the American Chemical Society, 138(46), 15197-15203.

9. Chen, M., Zheng, W., & Wolynes, P. G. (2016). Energy landscapes of a mechanical prion and their implications for the molecular mechanism of long-term memory. Proceedings of the National Academy of Sciences, 113(18), 5006-5011.