Xiaoliang Sunney XIE
Contact：sunneyxie@cpl.ac.cn
Education
1985-1990 Ph.D. in Physical Chemistry from University of California at San Diego
1980-1984 B.Sc. in Chemistry from Peking University
Academic Experience
2020-present Director, Changping Laboratory
2019-present Head of Faculty of Sciences, Peking University
2018-present Lee Shau-kee Professor, Peking University
2016-2022 Director of Beijing Advanced Innovation Center for Genomics, Peking University
2010-2022 Director of Biomedical Pioneering Innovation Center, Peking University
2009-2018 Mallinckrodt Professor of Chemistry and Chemical Biology, Harvard University
1999-2009 Full Professor of Chemistry, Harvard University
1992-1998 Senior Research Scientist to Chief Scientist, Environmental Molecular Sciences Laboratory, Pacific Northwest National Laboratory
1990-1992 Postdoctoral Fellow, University of Chicago
Overview of Academic Research
Xie has been a pioneer of single-molecule biophysical chemistry, coherent Raman scattering microscopy and single-cell genomics. The single-cell whole genome amplification methods that his group invented has to date benefited thousands of families with monogenic diseases by successfully preventing the passing of disease-causing mutations to their offspring. In fighting against the COVID-19 pandemic, Xie’s team has identified broad-spectrum neutralizing antibodies against all SARS-CoV-2 variants, which have been licensed to major pharmaceutical company.
Major Honor and Awards
Xie received numerous international awards, most notably Albany Prize in Medicine and Biomedical Research in 2015, Peter Debye Award in Physical Chemistry of American Chemical Society in 2015 and Founders Award of Biophysical Society in 2012.
Representative Research Achievements
1. Cao, Yunlong; Jian, Fanchong; Wang, Jing; Yu, Yuanling; Song, Weiliang; Yisimayi, Ayijiang; Wang, Jing; An, Ran; Chen, Xiaosu; Zhang, Na; Wang, Yao; Wang, Peng; Zhao, Lijuan; Sun, Haiyan; Yu, Lingling; Yang, Sijie; Xiao, Tianhe; Gu, Qingqing; Shao, Fei; Hao, Xiaohua; Xu, Yanli; Jin, Ronghua; Shen, Zhongyang; Wang, Youchun; Xie, Xiaoliang Sunney "Imprinted SARS-CoV-2 humoral immunity induces convergent Omicron RBD evolution," Nature, DOI: 10.1038/s41586-022-05644-7 (2022)
2. Cao, Yunlong; Wang, Jing; Jian, Fanchong; Xiao, Tianhe; Song, Weiliang; Yasimayi, Ayijiang; Huang, Weijin; Li, Qianqian; Wang, Peng; An, Ran; Wang, Jing; Wang, Yao; Niu, Xiao; Yang, Sijie; Liang, Hui; Sun, Haiyan; Li, Tao; Yu, Yuanling; Cui, Qianqian; Liu, Shuo; Yang, Xiaodong; Du, Shuo; Zhang, Zhiying; Hao, Xiaohua; Shao, Fei; Jin, Ronghua; Wang, Xiangxi; Xiao, Junyu; Wang, Youchun; Xie, Xiaoliang Sunney "Omicron escapes the majority of existing SARS-CoV-2 neutralizing antibodies," Nature 602, 657-663 DOI: 10.1038/s41586-021-04385-3 (2021)
3. Cao, Yunlong; Su, Bin; Guo, Xianghua; Sun, Wenjie; Deng, Yongqiang; Bao, Linlin; Zhu, Qinyu; Zhang, Xu; Zheng, Yinghui; Geng, Chenyang; Chai, Xiaoran; He, Runsheng; Li, Xiaofeng; Lv, Qi; Zhu, Hua; Deng, Wei; Xu, Yanfeng; Wang, Yanjun; Qiao, Luxin; Tan, Yafang; Song, Liyang; Wang, Guopeng; Du, Xiaoxia; Gao, Ning; Liu, Jiangning; Xiao, Junyu; Su, Xiaodong; Du, Zongmin; Feng, Yingmei; Qin, Chuan; Qin, Chengfeng; Jin, Ronghua; Xie, X. Sunney "Potent Neutralizing Antibodies against SARS-CoV-2 Identified by High-Throughput Single-Cell Sequencing of Convalescent Patients' B Cells," Cell 182(1), 73-84.e16 DOI: 10.1016/j.cell.2020.05.025 (2020)
4. Huang, Lei; Bogale, Berhan; Tang, Yaqiong; Lu, Sijia; Xie, X.Sunney; Racowsky, Catherine "Noninvasive preimplantation genetic testing for aneuploidy in spent medium may be more reliable than trophectoderm biopsy," PNAS 16(208), 14105-14112 DOI: 10.1073/pnas.1907472116 (2019)
5. Tan, Longzhi; Xing, Dong; Chang, Chi-Han; Li, Heng; Xie, X.Sunney "Three-dimensional genome structures of single diploid human cells," Science 43, 924-928 DOI: 10.1126/science.aat5641 (2018)
6. Chen, Chongyi; Xing, Dong; Tan, Longzhi; Li, Heng; Zhou, Guangyu; Huang, Lei; Xie, Xiaoliang S. "Single-cell whole-genome analyses by Linear Amplification via Transposon Insertion (LIANTI)," Science 356, 189-194 DOI: 10.1126/science.aak9787 (2017)
7. Yan, Liying; Huang, Lei; Xu, Liya; Huang, Jin; Ma, Fei; Zhu, Xiaohui; Tang, Yaqiong; Liu, Mingshan; Lian, Ying; Liu, Ping; Li, Rong; Lu, Sijia; Tang, Fuchou; Qiao, Jie; Xie, X. Sunney "Live births after simultaneous avoidance of monogenic diseases and chromosome abnormality by next-generation sequencing with linkage analyses," Proc Natl Acad Sci USA 112(52), 15964-15969 DOI: 10.1073/pnas.1523297113 (2015)
8. Chong, Shasha; Chen, Chongyi; Ge, Hao; Xie, X. Sunney "Mechanism of Transcriptional Bursting in Bacteria," Cell 158(2), 314-326 DOI: 10.1016/j.cell.2014.05.038 (2014)
9. Kim, S.; Brostromer, E.; Xing, D.; Jin, J.; Chong, S.; Ge, H.; Wang, S.; Gu, C.; Yang, L.; Gao, Y. Q.; Su, X.-d.; Sun, Y.; Xie, X. S. "Probing Allostery Through DNA," Science 339(6121), 816-819 DOI: 10.1126/science.1229223 (2013)
