Influenza A (H3N2) virus (A/H3N2) has complex antigenic evolution, resulting in frequent vaccine strain updates. We aimed to evaluate the protective effect of the vaccine strains on the circulating strains from past ten years and provide a basis for finding a broader and more efficient A/H3N2 vaccine strain.
Cultural differences and biological diversity play important roles in shaping human brain structure and function.
Continuous evolution of Omicron has led to a rapid and simultaneous emergence of numerous variants that display growth advantages over BA.5 1. Despite their divergent evolutionary courses, mutations on their receptor-binding domain (RBD) converge on several hotspots.
SARS-CoV-2 Omicron sublineages have escaped most RBD-targeting therapeutic neutralizing antibodies (NAbs), which proves the previous NAb drug screening strategies deficient against the fast-evolving SARS-CoV-2. Better broad NAb drug candidate selection methods are needed.
Multimodal neuroimaging plays an important role in neuroscience research.Integrated noninvasive neuroimaging modalities, such as magnetoencephalography(MEG),electroencephalography (EEG) and functional near-infrared spectroscopy(fNIRS),allow neural activity and related physiological processes in the
The type II AAA + ATPase Drg1 is a ribosome assembly factor, functioning to release Rlp24 from the pre-60S particle just exported from nucleus, and its activity in can be inhibited by a drug molecule diazaborine.
Durable antibody immunity depends on long-lived plasma cells (LLPCs) that primarily reside in the bone marrow (BM).
Substantial clinical heterogeneity and comorbidity inherent amongst mental disorders limit the identification of neuroimaging biomarkers that can reliably track clinical symptoms.
Blocking PD-1/PD-L1 signaling transforms cancer therapy and is assumed to unleash exhausted tumor-reactive CD8+ T cells in the tumor microenvironment (TME). However, recent studies have also indicated that the systemic tumor-reactive CD8+ T cells may respond to PD-1/PD-L1 immunotherapy.
Recently emerged SARS-CoV-2 Omicron subvariant,BA.2.75,displayed a local growth advantage over BA.2.38,BA.2.76 and BA.5 in India.The underlying mechanism of BA.2.75's enhanced infectivity, especially compared to BA.5,remains unclear.Herewe show that BA.2.75 exhibits substantially higher ACE2-binding