教育经历

工作经历

2024-至今 北大-清华生命科学联合中心，研究员、博士生导师
2023-至今 北京大学生物医学前沿创新中心(BIOPIC)，研究员、tenure-track助理教授

2020-至今 昌平国家实验室，领衔科学家
2022-2023 北京大学生物医学前沿创新中心(BIOPIC)，副研究员
2019-2022 北京大学生物医学前沿创新中心(BIOPIC)，助理研究员

研究简介

曹云龙课题组致力于在单细胞和分子水平开展体液免疫与抗体研究，聚焦以下研究方向：

l 传染性疾病中的抗体响应、免疫逃逸与免疫印迹；

l 广谱抗体药物开发与广谱疫苗设计；

l 解析不同表位抗体的功能差异及其机制；

l 基于高通量实验数据与机器学习模型的抗原表位特异性抗体人工设计。

主要荣誉

2025  何享健青年科学家奖

2025  北京市自然科学奖（一等奖）

2024  霍英东教育基金会高等院校青年科学奖

2024  科学探索奖

2024  达摩院青橙奖

2023  2022年度北京市杰出青年中关村奖

2023  WHO新冠疫苗成分技术指导委员会（TAG-CO-VAC）顾问

2023  流行病防范创新联盟（CEPI）科学咨询委员会委员

2023   2022年度中国科学十大进展

2023   2022年度中国生命科学十大进展

2022   2022年度 Nature 十大人物

2022   国家自然科学基金委优秀青年科学基金

2022  《麻省理工科技评论》2021 年度中国“35 岁以下科技创新 35 人”（TR35）

代表性成果

1. Fanchong Jian, Jing Wang, Ayijiang Yisimayi, Weiliang Song, Yanli Xu, Xiaosu Chen, Xiao Niu, Sijie Yang, Yuanling Yu, Peng Wang, Haiyan Sun, Lingling Yu, Jing Wang, Yao Wang, Ran An, Wenjing Wang, Miaomiao Ma, Tianhe Xiao, Qingqing Gu, Fei Shao, Youchun Wang, Zhongyang Shen, Ronghua Jin, Yunlong Cao*. Evolving antibody response to SARS-CoV-2 antigenic shift from XBB to JN.1. Nature. 637: 921-929 (2024).

2. Ayijiang Yisimayi, Weiliang Song, Jing Wang, Fanchong Jian, Yuanling Yu, Xiaosu Chen, Yanli Xu, Sijie Yang, Xiao Niu, Tianhe Xiao, Jing Wang, Lijuan Zhao, Haiyan Sun, Ran An, Na Zhang, Yao Wang, Peng Wang, Lingling Yu, Zhe Lv, Qingqing Gu, Fei Shao, Ronghua Jin, Zhongyang Shen, Xiaoliang Sunney Xie, Youchun Wang, Yunlong Cao*. Repeated Omicron exposures override ancestral SARS-CoV-2 immune imprinting. Nature. 625: 148-156. (2024).

3. Yunlong Cao*, Fanchong Jian, Jing Wang, Yuanling Yu, Weiliang Song, Ayijiang Yisimayi, Jing Wang, Ran An, Xiaosu Chen, Na Zhang, Yao Wang, Peng Wang, Lijuan Zhao, Haiyan Sun, Lingling Yu, Sijie Yang, Xiao Niu, Tianhe Xiao, Qingqing Gu, Fei Shao, Xiaohua Hao, Yanli Xu, Ronghua Jin, Zhongyang Shen, Youchun Wang*, Xiaoliang Sunney Xie*. Nature. 614: 21-529. (2023).

4. Yunlong Cao*, Ayijiang Yisimayi, Fanchong Jian, Weiliang Song, Tianhe Xiao, Lei Wang, Shuo Du, Jing Wang, Qianqian Li, Xiaosu Chen, Yuanling Yu, Peng Wang, Zhiying Zhang, Pulan Liu, Ran An, Xiaohua Hao, Yao Wang, Jing Wang, Rui Feng, Haiyan Sun, Lijuan Zhao, Wen Zhang, Dong Zhao, Jiang Zheng, Lingling Yu, Can Li, Na Zhang, Rui Wang, Xiao Niu, Sijie Yang, Xuetao Song, Yangyang Chai, Ye Hu, Yansong Shi, Linlin Zheng, Zhiqiang Li, Qingqing Gu, Fei Shao, Weijin Huang, Ronghua Jin, Zhongyang Shen*, Youchun Wang*, Xiangxi Wang*, Junyu Xiao*, Xiaoliang Sunney Xie*. BA.2.12.1, BA.4 and BA.5 escape antibodies elicited by Omicron infection. Nature. 608: 593-602. (2022).

5. Yunlong Cao*, Jing Wang, Fanchong Jian, Tianhe Xiao, Weiliang Song, Ayijiang Yisimayi, Weijin Huang, Qianqian Li, Peng Wang, Ran An, Jing Wang, Yao Wang, Xiao Niu, Sijie Yang, Hui Liang, Haiyan Sun, Tao Li, Yuanling Yu, Qianqian Cui, Shuo Liu, Xiaodong Yang, Shuo Du, Zhiying Zhang, Xiaohua Hao, Fei Shao, Ronghua Jin, Xiangxi Wang*, Junyu Xiao*, Youchun Wang*, Xiaoliang Sunney Xie*. Omicron escapes the majority of existing SARS-CoV-2 neutralizing antibodies. Nature. 602: 657-663. (2022).

6. Yunlong Cao, Bin Su, Xianghua Guo, Wenjie Sun, Yongqiang Deng, Linlin Bao, Qinyu Zhu, Xu Zhang, Yinghui Zheng, Chenyang Geng, Xiaoran Chai, Runsheng He, Xiaofeng Li, Qi Lv, Hua Zhu, Wei Deng, Yanfeng Xu, Yanjun Wang, Luxin Qiao, Yafang Tan, Liyang Song, Guopeng Wang, Xiaoxia Du, Ning Gao, Jiangning Liu, Junyu Xiao, Xiao-Dong Su, Zongmin Du, Yingmei Feng, Chuan Qin*, Chengfeng Qin*, Ronghua Jin*, Xiaoliang Sunney Xie*. Potent Neutralizing Antibodies against SARS-CoV-2 Identified by High-Throughput Single-Cell Sequencing of Convalescent Patients’ B Cells. Cell. 182: 73-84.e16 (2020).

7. Fanchong Jian, Anna Z. Wec, Leilei Feng, Yuanling Yu, Lei Wang, Peng Wang, Lingling Yu, Jing Wang, Jacob Hou, Daniela Montes Berrueta, Diana Lee, Tessa Speidel, LingZhi Ma, Thu Kim, Ayijiang Yisimayi, Weiliang Song, Jing Wang, Lu Liu, Sijie Yang, Xiao Niu, Tianhe Xiao, Ran An, Yao Wang, Fei Shao, Youchun Wang, Simone Pecetta, Xiangxi Wang*, Laura M. Walker*, Yunlong Ca*. Viral evolution prediction identifies broadly neutralizing antibodies to existing and prospective SARS-CoV-2 variants. Nature Microbiology 10: 2003-2017 (2025).

8. Sijie Yang, Yuanling Yu, Yanli Xu, Fanchong Jian, Weiliang Song, Ayijiang Yisimayi, Peng Wang, Jing Wang, Jingyi Liu, Lingling Yu, Xiao Niu, Jing Wang, Yao Wang, Fei Shao, Ronghua Jin, Youchun Wang, Yunlong Cao*. Fast evolution of SARS-CoV-2 BA.2.86 to JN.1 under heavy immune pressure. The Lancet Infectious Diseases. 24(2): e70-e72 (2024).

9. Can Yue, Weiliang Song, Lei Wang, Fanchong Jian, Xiaosu Chen, Fei Gao, Zhongyang Shen, Youchun Wang, Xiangxi Wang*, Yunlong Cao*. ACE2 binding and antibody evasion in enhanced transmissibility of XBB.1.5. The Lancet Infectious Diseases. 23(3):278-280 (2023).

10. Zhen Cui, Pan Liu, Nan Wang, Lei Wang, Kaiyue Fan, Qianhui Zhu, Kang Wang, Ruihong Chen, Rui Feng, Zijing Jia, Minnan Yang, Ge Xu, Boling Zhu, Wangjun Fu, Tianming Chu, Leilei Feng, Yide Wang, Xinran Pei, Peng Yang, Xiaoliang Sunney Xie, Lei Cao*, Yunlong Cao*, Xiangxi Wang*. Structural and functional characterizations of infectivity and immune evasion of SARS-CoV-2 Omicron. Cell. 185(5): 860-871. (2022).