教育经历

2007-2012，Singapore-MIT Alliance，Computational and System Biology，Ph.D

2003-2007，武汉大学，生物科学学院，学士

工作经历

2025.10-至今，昌平实验室，领衔科学家

2023.02-2026.01，南京大学模式动物研究所，所长

2018.09-至今，南京大学/国家遗传工程小鼠资源库/医药生物技术全国重点实验室，教授/研究员

2016.06-2018.06，法国巴斯德研究所，助理研究员

2012.07-2016.05，法国巴斯德研究所，博士后

研究简介

以人源化小鼠为核心工具，针对动物模型与人体的物种差异所导致的转化难题，做“以人为本”的科研，聚焦以下四个方向的研究：1.免疫系统与器官全人源化小鼠模型研发；2.肿瘤、衰老与退行性疾病的发病机制解析；3.人特异性免疫治疗靶点与药物发现；4.基于人源化小鼠获取或优化细胞、抗体与基因治疗药物。以通讯作者（含共通讯）在Cell, Cancer Cell, Cell Research, Nature Cancer等重要期刊中发表论文，并授权转化多项专利，研究成果实现了人源化小鼠模型的产业自主，发现和推动了多项免疫治疗药物与方案进入临床。

主要荣誉

2025，中国细胞生物学会青年科学家（入围奖），

2024，中国生物医药产业链创新转化联合体影响力U45青年奖

2023，江苏省前沿首届“攀登计划”领衔科学家

2021，国家自然科学基金委优青

2019，国家重点研发计划青年项目首席

2020，江苏省“双创团队领军人才”

2019，江苏省“特聘教授”

2013(Seoul)、2016(Zurich)，Outstanding Young Investigator, International Workshop on Humanized Mice

代表性成果

1. Chunyu Cheng#, Jing Sun#, Chun Lu#, Qian Yu#, Yiyun He, Bingqing Wu, Deshan Ren, Shuai Ding*, Jincun Zhao*, Yan Li*. (2025) A Lung-Immune Dual-Humanized Mouse Using Cryopreserved Tissue Enables Infection and Immune Profiling of Human Common Cold Coronaviruses, Advanced Science, DOI : 10.1002/advs.202512097

2. Wei Liu#, Tao Shi#, Chun Lu , Keying Che , Zijian Zhang , Yuting Luo , Daniel Hirschhorn,, Hanbing Wang , Shaorui Liu , Yan Wang , Shuang Liu , Haiqiao Sun, Jun Lu , Yuan Liu , Dongquan Shi , Shuai Ding , Heping Xu , Liaoxun Lu , Jianming Xu , Jun Xin , Yinming Liang ,Taha Merghoub*, Jia Wei*, Yan Li*. (2025) Human myelocyte and metamyelocyte-stage neutrophils suppress tumor immunity and promote cancer progression. Cell Research. DOI:10.1038/s41422-025-01145-0

3. Tao Shi#, Wei Liu#, Yuting Luo, Kaijie Liang, Shiji Ren, Xueru Song, Fangcen Liu, Chun Lu, Daniel Hirschhorn, Hanbing Wang, Yipeng Zhang, Yiran Cai1, Yue Wang, Yunfeng Pan, Wenqi Liu, Yang Nie, Ziliang Zhang, Lixia Yu,Shuai Ding, Baorui Liu, Taha Merghoub*, Yan Li*, Jia Wei* (2025). Chil3+ immature neutrophils inhibit anti-tumor immunity and impedeimmune checkpoint blockade therapy in bone metastases. Cancel Cell. DOI :10.1016/j.ccell.2025.07.007

4. Xueru Song#, Chun Lu#, Tao Shi#, Hanbing Wang, Wei Liu, Yuting Luo, Xiaoyu Zhou, Yue Wang, Shiji Ren, Lixia Yu, Baorui Liu, Yan Li*, Jia Wei*(2025) MHC II-restricted neoantigen vaccine reverses immune microenvironment and overcomes resistance to immune checkpoint inhibitors in cold tumors, Med, DOI:10.1016/j.medj.2025.100936

5. Shuang Liu#, Lin-Xing Wei#, Qian Yu#, Zhi-Wei Guo, Chang-You Zhan, Lei-Lei Chen*, Yan Li*, Dan Ye*. (2025, cover story) Targeting IRG1 in tumor-associated macrophages for cancer therapy. Protein & Cell. DOI: 10.1093/procel/pwaf012

6. Jiancheng Gao# , Danling Gu# , Kailin Yang# , Junxia Zhang# , Qiankun Lin# , Wei Yuan# , Xu Zhu# , Deobrat Dixit , Ryan C Gimple , Hao You , Qian Zhang , Zhumei Shi , Xiao Fan , Qiulian Wu , Chenfei Lu , Zhangchun Cheng , Daqi Li , Linjie Zhao , Bin Xue , Zhu Zhu , Zhe Zhu , Hui Yang , Ningwei Zhao , Wei Gao , Yingmei Lu , Junfei Shao , Chuandong Cheng , Dapeng Hao , Shuo Yang , Yun Chen , Xiaoming Wang , Chunsheng Kang , Jing Ji , Jianghong Man , Sameer Agnihotri , Qianghu Wang , Fan Lin , Xu Qian , Stephen C Mack , Zhibin Hu , Chaojun Li , Michael D Taylor , Yan Li* , Nu Zhang* , Jeremy N Rich* , Yongping You* , Xiuxing Wang*.(2025)Infiltrating plasma cells maintain glioblastoma stem cells through IgG-Tumor binding. Cancer Cell. DOI: 10.1016/j.ccell.2024.12.006

7. Feng Lin, Shenyi Yin,  Zijian Zhang, Ying Yu, Haoming Fang, Zhen Liang, Rujie Zhu, Haitao Zhou, Jianjie Li, Kunxia Ca, Weiming Guo, Shan Qin, Yuxuan Zhang, Chenghao Lu, Han Li, Shibo Liu, Heng Zhang, Buqing Ye, Jian Lin*, Yan Li*, Xiaozheng Kang*, Jianzhong Jeff Xi*, Peng R. Chen*. (2024) Multimodal targeting chimeras enable integrated immunotherapy leveraging tumor-immune microenvironment. Cell. DOI: 10.1016/j.cell.2024.10.016


8. Xiangyu Chen, Jing Zhao, Shuai Yue, Ziyu Li, Xiang Duan, Yao Lin, Yang Yang, Leiqiong Gao, Zhiwei Pan, Xiaofan Yang, Xingxing Su, Min Huang, Xiao Li, Ye Zhao, Xuehui Zhang, Zhirong Li, Li Hu, Jianfang Tang, Yaxing Hao, Qin Tian, Yifei Wang, Lifan Xu, Qizhao Huang, Yingjiao Cao, Yaokai Chen, Bo Zhu, Yan Li*, Fan Bai*, Guozhong Zhang*, Lilin Ye*. (2024) Targeting tumor cells toward the antigenic specificity of bystander T cells in tumor microenvironment potentiates cancer immunotherapy. Nature Cancer. Doi:10/1038/s43018-024-00760-x

9. Yan Li, Guillemette Masse Ranson, Zacarias Garcia, Timothee Bruel, Ayrin Kok-Harunova, Helene Strick-Marchand, Gregory Jouvion, Nicolas Serafini, Ai Ing Lim, Mathilde Dusseaux, Thierry Hieu, Frank Bourgade, Antoine Toubert, Daniela Finke, Oliver Schwartz, Phillippe Bousso, Hugo Mouquet and James P. Di Santo. (2018) A human immune system mouse model with robust lymph node development. Nature Methods 10.1038/s41592-018-0071-6

10. Yan Li, Helene Strick-Marchand, Ai Ing Lim, Jiazi Ren, Guillemette Masse-Ranson, Dan Li, Gregory Jouvion, Lars Rogge, Sophie Lucas, Bin Li and James P. Di Santo. (2017) Regulatory T cells control toxicity in a humanized model of IL-2 therapy. Nature Communications doi: 10.1038/s41467-017-01570-9.