教育经历

1986年 北京医科大学研究生院，医学硕士

1980年 上海医科大学公共卫生学院

工作经历

1997/03 至今         中国医学科学院中国协和医科大学肿瘤研究所研究员/教授、博士生导师

1996/06~1997/02 美国国家毒理学研究中心分子流行病学研究室高级访问学者

1995/11~1996/05中国医学科学院中国协和医科大学肿瘤研究所副研究员

1994/09~1995/10 中国预防医学科学院营养及食品卫生研究所副研究员

1990/07~1994/08 美国国家毒理学研究中心分子流行病学研究室访问学者

1989/06~1990/06 国际癌症研究中心(IARC, 法国里昂)进修学者

1988/10~1989/05 法国国家科学研究中心肿瘤研究所进修学者

1986/09~1988/09 福建医学院助教、讲师

研究简介

揭示我国食管癌、胰腺癌、肺癌等重要肿瘤的遗传易感基因和基因组变异、易感基因与环境的交互作用以及基因组变异对肿瘤治疗和预后的影响。

主要荣誉

2013年 国家自然科学奖二等奖

2013年 国家科技进步奖一等奖

2011年 教育部自然科学奖一等奖

2008年 国家科技进步奖二等奖

2006年 国家自然科学奖二等奖

代表性成果

1  Yamei Chen, Shihao Zhu, Tianyuan Liu, Shaosen Zhang, Juting Lu, Wenyi Fan, Lin Lin, Tao Xian, Jie Yang, Xuan Zhao, Yiyi Xi, Yulin Ma, Guoyu Chen, Dongxin Lin*, Chen Wu*. Epithelial cells activate fibroblasts to promote esophageal cancer development. Cancer Cell, 2023;41:xx-xx, in press.

2  Shuang Deng, Jialiang Zhang, Jiachun Su, Zhixiang Zuo, Lingxing Zeng, Kaijing Liu, Yanfen Zheng, Xudong Huang, Ruihong Bai, Lisha Zhuang, Ying Ye, Mei Li, Ling Pan, Junge Deng, Guandi Wu, Rui Li, Shaoping Zhang, Chen Wu, Dongxin Lin*, Jianjun Chen* Jian Zheng*. RNA m6A regulates transcription via DNA demethylation and chromatin accessibility. Nat Genet, 2022; 54:1427–1437.

3  Li R, Di L, Li J, Fan W, Liu Y, Guo W, Liu W, Liu L, Li Q, Chen L, Chen Y, Miao C, Liu H, Wang Y, Ma Y, Xu D, Lin D*, Huang Y*, Wang J*, Bai F*, Wu C*. A body map of somatic mutagenesis in morphologically normal human tissues. Nature, 2021;597:398–403.

4  Weiling Liu, Chuanwang Miao, Shaosen Zhang, Yachen Liu, Xiangjie Niu, Yiyi Xi, Wenjia Guo, Jiahui Chu, Ai Lin, Hongjin Liu, Xinyu Yang, Xinjie Chen, Ce Zhong, Yuling Ma, Yuqian Wang, Shihao Zhu, Shuning Liu, Wen Tan, Dongxin Lin*, Chen Wu*. VAV2 is required for DNA repair and implicated in cancer radiotherapy resistance. Signal Transduct Target Ther, 2021; 6:2906–2919.

5  Yuan Lin, Yinyin Luo, Yanxia Sun Y, Wenjia Guo, Xuan Zhao, Yiyi Xi, Yulin Ma, Mingming Shao, Wen Tan, Ge Gao*, Chen Wu*, Dongxin Lin*. Genomic and transcriptomic alterations associated with drug vulnerabilities and prognosis in adenocarcinoma at the gastroesophageal junction. Nat Commun, 2020;11:6091.

6  Jiang Chang, Rong Zhong, Jianbo Tian, Jiaoyuan Li, Kan Zhai, Juntao Ke, Jiao Lou, Wei Chen, Beibei Zhu, Na Shen, Yi Zhang, Ying Zhu, Yajie Gong, Yang Yang, Danyi Zou, Xiating Peng, Zhi Zhang, Xuemei Zhang, Kun Huang, Tangchun Wu, Chen Wu*, Xiaoping Miao* Dongxin Lin. Exome-wide analyses identify low-frequency variant in CYP26B1 and additional coding variants associated with esophageal squamous cell carcinoma. Nat Genet, 2018; 50:338–343.

7  Yanjie Zhao Lixuan Wei Mingming Shao Xudong Huang Jiang Chang Jian Zheng, Jiahui Chu Qionghua Cui Linna Peng Yingying Luo Wenle Tan Wen Tan, Dongxin Lin* Chen Wu*. BRCA1 associated protein increases invasiveness of esophageal squamous-cell carcinoma. Gastroenterology, 2017;153:1304–1319.

8  Jian Zheng, Xudong Huang, Wen Tan, Dianke Yu, Zhongli Du, Jiang Chang, Lixuan Wei, Yaling Han, Chengfeng Wang, Xu Che, Yifeng Zhou, Xiaoping Miao, Guoliang Jiang, Xianjun Yu, Xianghong Yang, Guangwen Cao, Chaohui Zuo, Zhaoshen Li, Chunyou Wang, Siu Tim Cheung, Yongfeng Jia, Xiongwei Zheng, Hongbing Shen, Chen Wu, Dongxin Lin. Pancreatic cancer risk variant in LINC00673 creates a miR-1231 binding site and interferes with PTPN11 degradation. Nat Genet, 2016; 48:747–757.

9  Chen Wu, Dong Li, Weihua Jia, Zhibin Hu, Yifeng Zhou, Dianke Yu, Tong Tong, Mingrong Wang, Dongmei Lin, Yan Qiao, Yuling Zhou, Jiang Chang, Kan Zhai, Menghan Wang, Lixuan Wei, Wen Tan, Hongbing Shen, Yixin Zeng, Dongxin Lin*. Genome-wide association study identifies common variants in SLC39A6 associated with length of survival in esophageal squamous-cell carcinoma patients. Nat Genet, 2013; 45:632–638.

10  Chen Wu, Peter Kraft, Kan Zhai, Jiang Chang, Zhaoming Wang, Yun Li, Zhibin Hu, Zhonghu He, Weihua Jia, Christian C Abnet, Liming Liang, Nan Hu, Xiaoping Miao, Yifeng Zhou, Zhihua Liu, Qimin Zhan, Yu Liu, Yan Qiao, Yuling Zhou, Guangfu Jin, Chuanhai Guo, Changdong Lu, Haijun Yang, Jianhua Fu, Dianke Yu, Neal D Freedman, Ti Ding, Wen Tan, Alisa M Goldstein, Tangchun Wu, Hongbing Shen, Yang Ke, Yixin Zeng, Stephen J Chanock, Philip R Taylor, Dongxin Lin*. Genome-wide association analyses of esophageal squamous cell carcinoma in Chinese identify multiple susceptibility loci and gene-environment interactions Nat Gent, 2012;244:1090–1097.