Education

1997-2002，Peking University，Inorganic Chemistry，Ph.D.

1993-1997，Peking University，Chemistry，B.S.

Academic Experience

2024-present，Changping Laboratory, Beijing，Scientist

2020-present，College of Chemistry and Molecular Engineering, Peking University，Professor

2015-present，Peking University-Tsinghua University Center for Life Sciences，Principal Investigator

2010-present，BIOPIC, Peking University，Principal Investigator

2013-2020，College of Engineering, Peking University，Professor

2006-2013，College of Engineering, Peking University，Principal Invesetigator

2005-2006，Stanford University，Postdoctoral Scholar in Bioengineering

2002-2005，California Institute of Technology，Postdoctoral Scholar in Applied Physics

Overview of Academic Research

Huang group focuses on the intersection of trace nucleic acid analytical chemistry, microfluidics, DNA sequencing technology, and high-throughput sequencing. We are committed to developing novel life analytical chemistry instruments and methods to achieve precise quantification and high-throughput measurement of complex biological systems. Through microfluidic chips, optical imaging, high-throughput sequencing, and mass spectrometry, we systematically explore the identification, amplification, and sequencing of trace nucleic acids from DNA to RNA to proteins, and promote innovation in single-cell analysis, spatial multi-omics, and ancient DNA analysis. The group has long persisted in independent instrument development and key technology breakthroughs, aiming to translate basic research results into effective tools for solving practical biomedical problems.

Key research areas include:

• Error-correcting code sequencing method and sequencer;

• High-throughput in-situ nucleic acid imaging method;

• A fuzzy sequencer for rapid DNA fragment counting and genotyping;

• Construction of high-quality ancient DNA genome data in complex archaeological sites.

Major Honor and Awards

2025，New Cornerstone Investigator

2021,“Changjiang Scholars Program” Distinguished Professor

2015，NSFC Distinguished Young Scholar Award

2014，Fellow of the Royal Society of Chemistry

2012，NSFC Excellent Young Scientist Award

2010，Fok Ying Tung Education Foundation Young Investigator Award

2008，Program for New Century Excellent Talents in University

2004，National Excellent Doctoral Thesis Award

 

Representative Research Achievements 

1.  Tianyi Chang,# Shihui Zhao,# Kunyue Deng,# Zhizhao Liao,# Mingchuan Tang,# Yanxi Zhu, Wuji Han, Chenxi Yu, Wenyi Fan, Mengcheng Jiang, Guanbo Wang, Dongfang Liu, Jirun Peng, Yuhong Pang, Peng Fei, Jianbin Wang, Chunhong Zheng,* Yanyi H.*,High-plex spatial RNA imaging in one round with conventional microscopes using color-intensity barcodes.Nat Biotechnol(2025).

2.  Zhou Wenxiong,# Kang Li,# Qiao Shuo,# Duan Haifeng,# Yin Chenghong,# Liu Chao,# Liao Zhizhao, Tang Mingchuan, Zhang Ruiying, Li Lei, Shi Lei, Du Meijie, Wang Yipeng, Yue Wentao, Xiao Yan, Di Lin, Zhang Xiannian, Pang Yuhong, Li Mingkun, Ren Lili, Wang Jianbin,* Chen Zitian,* and Huang Yanyi*,A fuzzy sequencer for rapid DNA fragment counting and genotyping.Nat. Biomed. Eng(2025).

3.  Wang Jincheng,# Yan Shi,# Li Zhenguang, Zan Jinguo, Zhao Yichao, Zhao Jin, Chen Kui, Wang Xueye, Ji Ting, Zhang Cheng, Yang Tingyu, Zhang Tianming, Qiao Rui, Guo Meilin, Rao Zongyue, Zhang Jiashuo, Wang Guanbo, Ran Zhiyu, Duan Chen, Zhang Fan, Song Yin, Wu Xiaohong, Mace Ruth, Sun Bo,* Pang Yuhong,* Huang Yanyi,* Zhang Hai* and Ning, Chao*,Ancient DNA reveals a two-clanned matrilineal community in Neolithic China.Nature643, 1304-1311 (2025).

4.  Zitian Chen, Wenxiong Zhou, Shuo Qiao, Li Kang, Haifeng Duan, X. Sunney Xie, Yanyi H*.,Nature Biotechnology35 (12), 1170-1178 (2017).

5.  Ruoyan Li,# Lin Di,# Jie Li,# Wenyi Fan,# Yachen Liu, Wenjia Guo, Weiling Liu, Lu Liu, Qiong Li, Liping Chen, Yamei Chen, Chuanwang Miao, Hongjin Liu, Yuqian Wang, Yuling Ma, Deshu Xu, Dongxin Lin,* Yanyi Huang,* Jianbin Wang,* Fan Bai,* Chen Wu*.Nature597 (7876), 398-403 (2021).