“事后看来，人类基因组计划与曼哈顿计划、阿波罗计划并列，是科学史上最成功的重大工程之一。”
“In hindsight, the Human Genome Project stands alongside the Manhattan Project and the Apollo Program as one of the most successful mega-projects in the history of science.”

“这本天书的破译，推动了生物学和医学几乎所有领域的发展。”
“The decoding of this heaven book has brought advances to almost every aspect in all fields of biology and medicine.”

“这是基因组学领域的一个辉煌时代。我会说，这是充满乐趣的，也充满压力的。”

“It was a great time to be in genomics. I will say it was a lot of fun, it was a lot of stress.”

基因组学本质上是一门依赖协作的科学，需要汇聚多元视角。主动寻求并倾听那些与你观点相异的声音，至关重要。

“Genomics really is a team science. It takes many perspectives. Find and listen to people who have different perspectives from yours.”

“如果它能挽救你所爱之人的生命，那么最重要的就不是技术本身的细节，而是这项技术的应用能为人们带来什么。”

“If it saves the life of somebody you love, what matters most isn’t the details of the technology itself, but what the application of that technology can do for people.”

“我完全没有预料到单细胞基因组学会如此重要——它对科学竟有如此深远的影响。那是我最大的意外。

“I completely missed how big single cell genomics would be and how important it would be to science. That was my big surprise.”

“人工智能无法解决所有问题。我们需要做的是结合观察数据、人工智能以及统计学，来加速发现。”
“AI cannot solve all the problems. What we need to do is basically leverage the observed data plus the AI and also plus the statistics in order to accelerate the discovery.”

“目标不仅仅是有所发现，而是要确保发现是真实的。”
“So the goal is not to just have a discovery, but this had to be a true discovery.”

“重要的不是预测，而是干预。我们应该思考的不是试图检测癌症，而是真正预防癌症。”
“It's not just about prediction. It's about intervention. What we should be thinking about is not just trying to detect cancer, but actually prevent it.”

“癌症并非体细胞进化的唯一归宿。其中一些选择实际上可能预防癌症。”

“Cancer is not the only destination of somatic evolution. Some of this selection may actually protect against cancer.”

“五年或十年内治愈所有疾病——我认为这被极度夸大了。这可能适得其反。”

"Curing all disease within 5 or 10 years — I think that's just vastly overhyped. I think it's a bit counterproductive."

“如果有一个机器人能走进实验室，从冰箱取出试剂，拧开试管盖，成功完成细胞培养实验——那我认为我们就成功了。”

“If we have a robot that can walk into the lab, take out reagents from the freezer, unscrew Eppendorf tubes, and run a cell culture experiment successfully — then I think we're there.”

“癌症不是单一疾病，而是数千种疾病的集合体。”
“Cancer is not one single disease, it's thousands of diseases.”

“就像元素周期表对化学至关重要一样，如果你想了解疾病组织内部发生了什么，你需要一个肿瘤内所有细胞类型的目录。”

“Just like the periodic table is fundamental to chemistry, if you want to understand what's going on inside diseased tissue, you need a catalog of all the cell types within the tumor.”

“尽管当前的人类参考基因组组装质量极高，影响深远，但它存在关键局限——它是一个伪基因组，代表的是单一嵌合单倍型。人类泛基因组计划正在构建真实个体的、已分相位的、端粒到端粒的二倍体基因组组装，以代表广泛的人类遗传多样性。”

“Despite being extremely high quality and impactful, the current human reference genome has key limitations—it is a fake genome representing a single mosaic haplotype. The human pangenome project is constructing phased, telomere-to-telomere diploid genome assemblies of actual individuals that represent broad human genetic diversity.”

“人类泛基因组计划不仅仅是自然科学项目，它也是一个社会科学项目，伦理和法律问题至关重要。”

“Human pan genome project, it's also a social science project. Ethical and legal issues are very, very important for us to consider.”

“DNA 是信息的源头，测序仪是信息传递的通道。”

“DNA is the information source; the sequencer is the communication channel.”

“在这一过程中我感受到了产业驱动的工程力量，与基础研究的科学之美”

“Through this journey I have enjoyed both the power of industry-driven engineering and the elegance of basic research.”

“我们希望通过耗材复用和化学创新，让测序成本不再成为大规模基因组学的障碍。”
“We aim to make cost no longer a barrier for large-scale genomics through consumable reuse and chemical innovation.”

 “非编码区不是‘垃圾’，而是疾病的调控开关。”
“Non-coding regions are not 'junk', but regulatory switches of disease.”

“我们不仅能修复基因，还能让细胞为争夺营养而‘饿死’肿瘤。”
“We can not only fix genes, but also make cells 'starve' tumors by competing for nutrients.”

“三维结构不是静态的脚手架，而是转录调控的动态平台。”
“3D structure is not a static scaffold, but a dynamic platform for transcriptional regulation.”

“那些线性上相距遥远的基因，在空间上常常可以聚集成簇，这为协同转录提供了结构基础。”

“Distant genes located within the nearby regions are not really transcribed independently; instead, they actually often can be clustered together in a proximity of spatial space, therefore providing the structural basis for coordinated transcription.”

“人工智能被低估了。它将极大地改变一切——被低估的是创造力。”

“AI is underestimated. It's going to dramatically change everything. The underestimated part is creativity.”

我们的见解是—用中文来说：毒蛇出没之处，七步之内必有解药。用英文来说：每个肿瘤内部都藏着战胜它的武器。

“Inside every tumor lies the weapons to defeat it.”

“我们利用AI收获自然的工程奇迹——与其翻遍那堆庞大的干草堆，不如用AI筛选出一份精炼的候选清单。”

“We use AI to harvest nature's engineering wonders. Instead of looking at a quintillion-size haystack, we just need to use AI to sort a curated short list.”

癌症早筛技术的性能随着数据的不断积累一定会打磨完善，然而想要在国家层面推进人群早期癌症筛查，卫生经济学这笔帐得算清楚。”
“The performance of cancer early screening technologies will undoubtedly be refined as data continues to accumulate. However, to advance population-level early cancer screening at the populational level, the health economics must be carefully calculated.”

“借助昌平实验室开发的创新高通量实验技术，我们得以设计AI模型，去探索那些尚未被充分研究的转录因子。”

“With innovative experimental high throughput technique developed at CPL, we are able to design Al to explore the understudied transcription factors.”

“低质量数据也很有用，取决于我们如何使用它。”

“The low quality data is also useful, but depending on the way how we use it.”

“从0到1更多靠的是技术、临床需求以及与临床端的紧密合作；从1到10或从10到100，更多靠的是标准与监管。每个国家法规不同、环境不同，技术必须本地化才能落地。”
"From 0 to 1 is more about technology, clinical needs, and close collaboration with the clinical side. However, from 1 to 10 or from 10 to 100 is more about criteria and regulation. Each country has different regulations and environments, so technology must be localized to succeed."

“我们需要将监管视为朋友，而不是试图阻止我们做事的人。没有监管，技术就无法大规模普及。”
“We need to treat regulation as a friend, not as someone that's trying to prevent us from doing things. Without regulation, no technology can go to scale.”