教育经历

1997-2003  德克萨斯州加尔韦斯顿医学院，实验病理学，博士

1991-1996  北京医科大学，临床医学，学士

工作经历

2021-至今   清华大学医学院，院长

2015-至今   清华大学医学院，终身教授

2009-2015  清华大学医学院，副教授

2003-2009  美国国立卫生研究院传染病与变态反应病研究所 (Laboratory of Immunology, NIAID/NIH)，免疫实验室，博士后研究员

研究简介

长期致力于研究体液免疫的动态调控及神经系统与免疫系统互作的机制，在B细胞生物学、滤泡辅助T细胞（Tfh）生物学及神经免疫生物学做出了系统性、开创性的成果。发现抗体亲和力成熟的细胞间正反馈机制、鉴定了记忆B细胞前体、揭示抗体应答雌雄二态性的细胞学基础、以及定义了第一条调控获得性免疫应答的脑-脾轴神经通路等。目前共发表70多篇SCI论文，多篇研究成果发表在《Nature》《Science》等重要期刊。

主要荣誉

2019  教育部高等学校科学研究优秀成果奖一等奖

2018  美国免疫学会研究者奖（AAI-BD Investigator Award）

2017  树兰医学青年奖

2017  霍华德休斯医学研究所国际学者（HHMI International Research Scholar）

2016  吴阶平-保罗杨森医学药学奖

2015  谈家桢生命科学创新奖

代表性成果

1.Xin Liu*, Jiacheng Yao*, Yongshan Zhao, Jianbin Wang#& Hai Qi#. Heterogeneous plasma cells and long-lived subsets in response to immunization, autoantigen and microbiota. Nature Immunology, 23, 1564-1576, 2022.

 

2.Dan Liu*, Jiacong Yan*, Jiahui Sun*, Bo Liu ,Weiwei Ma ,Ye Li, Xingxing Shao , Hai Qi# , BCL6 controls contact-dependent help delivery during follicular T-B cell interactions. Immunity, 54: 2245-2255.e4, 2021.

 

3.Bo Liu, Yihan Lin, Jiacong Yan, Jiacheng Yao, Dan Liu, Weiwei Ma, Jianbin Wang, Wanli Liu, Chengshuo Wang, Luo Zhang, and Hai Qi#. Affinity-coupled CCL22 promotes positive selection in germinal centres. Nature, 592:133-137, 2021.

4.Xu Zhang*, Bo Lei*, Yuan Yuan*, Li Zhang*, Lu Hu, Sen Jin, Bilin Kang, Xuebin Liao, Wenzhi Sun, Fuqiang Xu, Yi Zhong#, Ji Hu# and Hai Qi#. Brain control of humoral immune responses amenable to behavioral modulation. Nature, 581:204-208, 2020.

5.Ruozhu Zhao, Xin Chen, Weiwei Ma, Jinyu Zhang, Jie Guo, Xiu Zhong, Jiacheng Yao, Jiahui Sun, Julian Rubinfien, Xuyu Zhou, Jianbin Wang and Hai Qi#. A GPR174-CCL21 module imparts sexual dimorphism to humoral immunity. Nature, 577:416-420, 2020.

6.Jingwen Shi, Shiyue Hou, Qian Fang, Xin Liu, Xiaolong Liu, and Hai Qi#. PD-1 controls follicular T helper cell positioning and function. Immunity, 49:264-274, 2018.

 

7.Yifeng Wang*, Jingwen Shi*, Jiacong Yan*, Zhengtao Xiao, Xiaoxiao Hou, Peiwen Lu, Shiyue Hou, Tianyang Mao, Wanli Liu, Yuanwu Ma, Lianfeng Zhang, Xuerui Yang and Hai Qi#. Germinal center development of memory B cells driven by Interleukin-9-producing follicular T-helper cells. Nature Immunology, 18:921-930, 2017

8.Peiwen Lu*, Changming Shih*, and Hai Qi#. Ephrin B1–mediated repulsion and signaling control germinal center T cell territoriality and function. Science, 356:eaai9264, 2017.

9.Ran He*, Shiyue Hou*, Cheng Liu*, Anli Zhang, Qiang Bai, Miao Han, Yu Yang, Gang Wei, Ting Shen, Xinxin Yang, Lifan Xu, Xiangyu Chen, Yaxing Hao, Chuhong Zhu, Juanjuan Ou, Houjie Liang, Ting Ni, Xiaoyan Zhang, Xinyuan Zhou, Jianqing Xu, Hai Qi#, Yuzhang Wu# and Lilin Ye#. Follicular CXCR5-expressing CD8 T cells curtail chronic viral infection. Nature, 537:412-428, 2016.

 

10.Dan Liu*, Heping Xu*, Changming Shih, Zurong Wan, Xiaopeng Ma, Weiwei Ma, Dan Luo, and Hai Qi#. T-B-cell entanglement and ICOSL-driven feed-forward regulation of germinal centre reaction. Nature, 517:214-218, 2015